Schematic diagram of the arteriovenous shunt and thrombogenic device used to study thrombosis in baboons. Thrombogenic devices contain a 20-mm long segment of ePTFE graft tubing (4-mm diameter) coated with collagen and a 20-mm expansion chamber made of silicon rubber tubing (9-mm diameter, 20-mm length) downstream of the collagen-coated segment. The collagen-coated segment and expansion chamber are connected by a 20-mm linker made of uncoated silicon tubing (4-mm diameter). Flow through the arterio-venous shunt is adjusted to 100 mL per minute by a flow restrictor, producing an initial shear rate in the collagen-coated portion of the thrombogenic device of 265 s⁻¹.