Role of FXa in vascular inflammation in SCD. (A-F) PT (A) and plasma levels of TAT (B), sVCAM-1 (C), IL-6 (D), and MPO (E) in the lungs and average number of neutrophils (F) in lungs of BERK^AA (n = 16) and BERK^SS (n = 13-15) mice fed with chow containing rivaroxaban (Riv) or placebo control (Con) for 10 days. Asterisks directly above bars indicate statistical significance between BERK^SS mice compared with BERK^AA mice within the same treatment group (Con or Riv) (*P < .05, **P < .01, ***P < .001).