Role of PAR-2 in vascular inflammation in SCD. (A-E) Plasma levels of TAT (A), sVCAM-1 (B), IL-6 (C), and MPO (D) and average number of neutrophils (E) in the lung of PAR-2^+/+ or PAR-2^−/− mice transplanted with bone marrow from WT (n = 8-9) or BERK (n = 8-12) mice. (F) Representative lung sections demonstrating neutrophil infiltration in four different groups of mice. Neutrophils stain as brown. Asterisks directly above the bars indicate statistically significant difference between BERK^BM mice compared with WT^BM mice within the same PAR-2 genotype (*P < .05, **P < .01, and ***P < .001).