Plg modulates phagocytosis-related genes in liver and spleen. Volcano plots of RT²PCR phagocytosis arrays comparing statistically significant gene expression changes in liver (A) and spleen (B) of Plg^+/+ mice to Plg^−/− mice. Log 2 values of the fold changes are plotted on the x-axis; the –log 10 transformed P values are plotted on the y-axis. The values are obtained from 3 replicates of raw Ct data. The solid line in the graphs marks the P value of .05, and the dotted line marks a onefold change. Thirty genes in the liver and 13 in the spleen were significantly downregulated in Plg^−/− compared with Plg^+/+ mice (top left, P ≤ .05). Twelve genes in the liver and 3 genes in the spleen were significantly upregulated (top right, P ≤ .05).