Ezh2 controls differentiation and survival of effector T cells in vivo. Chimera mice (n = 5-8/group) were IV injected with 2 × 10⁴ LM. Results shown are (A) CD4⁺ T cells that are IFN-γ producing Th1 cells 5 days postinfection; and (B) IFN-γ producing CD4⁺ and CD8⁺ T cells 6 days postinfection. (C) Four weeks after primary infection with 1 × 10⁴ LM, mice were rechallenged with 2 × 10⁵ LM. The phenotype of spleen CD4⁺ T cells and the bacterial number in spleen and liver lysates were determined 3 days after the second infection. Results shown are from 3 independent experiments. Unpaired Student t test: **P < .01.