EZH2 suppresses IFN-γ production and death of human CD4⁺ T cells. (A) IFN-γ and FOXP3 expression in human Th0 and iTreg cells in the absence or presence of EZH2 inhibitor GSK-126. (B) Proportion of IFN-γ Th0 cells and (C) FOXP3 iTreg cells with or without EZH2 inhibitor GSK-126 during naïve cell differentiation in healthy individuals. (D) Fold change in day 6 differentiated cell number compared with day 0 naïve CD4⁺ T-cell input. Paired Student t test: 2-tailed for (B-D). (E) Expression of PRC2 components during naïve CD4⁺ T-cell differentiation.