Treatment with low doses of RG7112 and Peg-IFNα 2a reduced the numbers of JAK2V617F⁺ cells in NOD/SCID mice. Combination treatment of PMF (A) and PV (B). Donor CD34⁺ cells treated with RG7112 and Peg-IFNα 2a in combination led to a greater reduction in JAK2V617F allele burden than that observed in recipient NSG mice transplanted with CD34⁺ cells treated with either agent alone.