Walters Figure 3.
Walters Figure 3. Gene therapy with hematopoietic stem cells (HSCs) and post-transduction selection. 42 . / Limiting numbers of MGMT-expressing gene-corrected cells are expanded by initially killing most of the of untransduced HSCs with BCNU and O6-benzylguanine (O6BG) therapy. Self-renewal and expansion of MGMT gene-corrected HSCs repopulate all hematopoietic lineages. / Reprinted with permission from Bank A. Hematopoietic stem cell gene therapy: selecting only the best. J Clin Invest. 2003;112(10):1478–1480.

Gene therapy with hematopoietic stem cells (HSCs) and post-transduction selection.42

Limiting numbers of MGMT-expressing gene-corrected cells are expanded by initially killing most of the of untransduced HSCs with BCNU and O6-benzylguanine (O6BG) therapy. Self-renewal and expansion of MGMT gene-corrected HSCs repopulate all hematopoietic lineages.

Reprinted with permission from

Bank A. Hematopoietic stem cell gene therapy: selecting only the best. J Clin Invest. 2003;112(10):1478–1480.

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