Top. Diagram of theRHlocus. The figure illustrates the inverted orientation of the RHD and RHCE genes and the deletion of RHD associated with the Rh-negative RBC phenotype.
 Bottom. Predicted 12-transmembrane model of the RhD and RhCE proteins in the erythrocyte membrane. The amino acid differences between RhD and RhCE are shown as circles. The zigzag lines represent the location of palmitoylation sites. Amino acid positions 103 and 226 on RhCE that are critical for C or c and E or e expression, respectively, are indicated.