Adhesive interactions between SS red blood cells, plasma proteins, and components of the endothelium. A large body of evidence supports the ability of multiple red cell surface structures to interact with plasma proteins, endothelial cell surface proteins, or components of the subendothelial extracellular matrix.

* Structures present on SS reticulocytes but not mature SS red blood cells.

Abbreviations: FBN, fibronectin; TSP, thrombospondin; ULvWF, ultra-large von Willebrand factor; ECM, extracellular matrix; LAM, laminin