Figure 1.
Diagnostic work-up, classification, and stratification of childhood non-Hodgkin lymphoma (NHL) subtypes into treatment groups.
*Growth pattern diffuse in T-cell–rich B-cell lymphoma (TCRB), nodular, or nodular and diffuse in NLPHL. An overlap between TCRB and NLPHL cannot be excluded at present.
**Rare cases of DLBCL (with immunoblast/plasmoblast-like cytology) express full-length Alk and can have t(2;17)(p23;q23) (Alkclathrin) translocation (Gascoyne RD 2003).
Abbreviations: TRBCL, T-cell rich B-cell lymphoma; PMLBL, primary mediastinal (thymic) large B-cell lymphoma; HL, Hodgkin lymphoma; NLPHL, nodular lymphocyte predominant Hodgkin lymphoma; NSHL, nodular sclerosis type Hodgkin lymphoma; PTCL/ NK, peripheral T-cell/natural killer-cell lymphoma; FISH, fluorescence in situ hybridization; PCR, polymerase chain reaction.