Pediatric ITP patients show increased proportions of platelets with p-selectin exposure and a decreased thrombin activation, which is normalized after IVIg treatment independent of the platelet count. (A) Platelet counts (Tc count), (B) proportion of platelets exposing p-selectin (% CD62p+ platelets) without and (C) with thrombin-stimulation (+ thrombin) were compared between children with ITP before and after IVIg treatment (ITP+IVIg), healthy control and cTP. The median and upper and lower quartiles are shown in boxes with whiskers for the range of data and open symbols for outliners.