MD snapshots of Imatinib (colored sticks) bound to (top) and “escaped” from (bottom) SCTABLI^V304D. The mutant residue D304 is highlighted in yellow. Note the rearrangement of the activation loop, the SH3 binding region, and the helix C, colored blue, spring green, and orange in the lower panel. Some waters and counterions are shown as colored spheres.