10 categories of histopathologically and clinically defined skin disease were studied by high-throughput sequencing of the TCRB and TCRG loci. “Box and whisker” plots of the TCRG analyses are shown. The boxed areas represent the second and third quartiles of the values of the top two TCRG sequences identified as a log fraction of the total nucleated cells in the study sample. Solid dots represent the median values. There is a clear demarcation between CTCL and LyP and the other categories of skin disease.