Changes in SOCS3 gene expression with time on lenalidomide plus prednisone treatment. Expression of SOCS3 increases significantly with time on treatment (P = 0.0002 using one-way analysis of variance). Mean expression at 9, 12 and > 14 months is significantly higher than at baseline, as assessed by Dunnett's multiple comparisons test. Data shown represent inverse relative expression. P < 0.05 was considered statistically significant.