John V. Dacie (1912–2005). Professor Dacie made many important contributions to the clinical and laboratory description of PNH during his tenure on the Pathology faculty of the Royal Postgraduate Medical School, Hammersmith Hospital, London. Among them was the connection between PNH and aplastic anemia. From this observation, he developed the hypothesis that PNH arises in the setting of bone marrow hypoplasia as the result of somatic mutation because in this setting “the abnormal cells must have some, as yet not understood biological advantage.”14 Although he retired in 1975, Professor Dacie’s remarkably clear vision continues to influence PNH research today. Professor Dacie was 87 years old when this photograph was taken. Reproduced from Rosse W. A Brief History of PNH. PNH and the GPI-Linked Proteins. San Diego: Academic Press; 2000:1–20 by copyright permission of Academic Press.
