Figure 1.
Effect of IL-6, IL-1α, and TNF-α on hypoxia-induced erythropoietin (Epo) mRNA levels. Hep3B cells were incubated under normoxic (21% O2) or hypoxic (1% O2) conditions in the presence or absence of the various cytokines, as indicated. Actin served as control. In addition, the amount of Epo produced by the cells was determined in duplicate by RIA as shown Reproduced with permission from Faquin et al. Effect of inflammatory cytokines on hypoxia-induced erythropoietin production. Blood 1992;79:1987–1994. © American Society of Hematology
