Partially scaled schematic diagram. The line diagrams summarize sample collection for each of the 9 patients (6 with RT and 3 without RT), with reference to ibrutinib (ibr) initiation (orange triangle). The samples to the left of ibr initiation represent the preibrutinib (pre-ibr) time points. The solid line to the right is log scaled. Types of sample are noted. Supplemental Table 2 provides more details about the samples.