Recurrent abnormalities detected in patients before ibrutinib initiation. (A) Recurring CNAs. Short and long arms of chromosomes are labeled, and centromeres are highlighted. Red bars represent single-copy loss, light red bars represent mosaic loss (SmoothSignal log2 ≥ 1.5), dark red bars represent homozygous loss, and blue bars represent gains. (B) Heatmap summarizing recurrent abnormalities in all 9 patients. Gray box indicates positive finding. *CLL021 shows complex structural abnormalities of chromosome 12 with concomitant whole-chromosome gain. Amp, amplification.