American Society of Hematology

Figure 2.

$Figure 2. Characterization of cells that engrafted in NSG and NSGS mice. (A) The fraction of human CD45+ (hCD45+) cells was measured by flow cytometry in blood, BM, and spleen of NSG (empty blue circles) and NSGS (empty red squares) mice engrafted with indicated CMML samples and euthanized 12 to 16 weeks after transplantation. (B) Hematoxylin and eosin (HE) staining and immunohistochemical analysis of hCD45+ cells on the BM, spleen, and liver of NSG (left panels) or NSGS (right panels) mice engrafted with CMML CD34+ cells sorted from S994. Original magnification ×200. (C) Concentration of human GM-CSF (hGM-CSF), SCF (hSCF), and IL-3 (hIL-s) detected in the plasma, BM, spleen, and liver of NSG (empty blue circles) and NSGS (empty red squares) mice.$

Characterization of cells that engrafted in NSG and NSGS mice. (A) The fraction of human CD45⁺ (hCD45⁺) cells was measured by flow cytometry in blood, BM, and spleen of NSG (empty blue circles) and NSGS (empty red squares) mice engrafted with indicated CMML samples and euthanized 12 to 16 weeks after transplantation. (B) Hematoxylin and eosin (HE) staining and immunohistochemical analysis of hCD45⁺ cells on the BM, spleen, and liver of NSG (left panels) or NSGS (right panels) mice engrafted with CMML CD34⁺ cells sorted from S994. Original magnification ×200. (C) Concentration of human GM-CSF (hGM-CSF), SCF (hSCF), and IL-3 (hIL-s) detected in the plasma, BM, spleen, and liver of NSG (empty blue circles) and NSGS (empty red squares) mice.

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