American Society of Hematology

Figure 1.

$Figure 1. Preclinical expansion of JAK2 V617F clones in 12 MPN patients. (A) Schema of blood sample collection from 12 individuals at the time of registration as stem cell donors at the Cyprus Bone Marrow Donor Registry and at the time they were diagnosed with MPN 4.6 to 15.2 years later. (B) Variant allele fraction (VAF) sizes of JAK2 V617F–positive clones at the 2 time points against the age of participants at the time. The specific diagnosis is indicated in brackets next to each patient’s ID, and the average annual rise in JAK2 V617F VAF is indicated in the upper right quadrant of each plot. Samples P3, P7, and P8 had no detectable JAK2 V617F at donor registration. The VAF rise for SRSF2 P95R in patient P3 is show in red.$

Preclinical expansion of JAK2 V617F clones in 12 MPN patients. (A) Schema of blood sample collection from 12 individuals at the time of registration as stem cell donors at the Cyprus Bone Marrow Donor Registry and at the time they were diagnosed with MPN 4.6 to 15.2 years later. (B) Variant allele fraction (VAF) sizes of JAK2 V617F–positive clones at the 2 time points against the age of participants at the time. The specific diagnosis is indicated in brackets next to each patient’s ID, and the average annual rise in JAK2 V617F VAF is indicated in the upper right quadrant of each plot. Samples P3, P7, and P8 had no detectable JAK2 V617F at donor registration. The VAF rise for SRSF2 P95R in patient P3 is show in red.

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