Treatment with all 4 concentrations of UFH and LMWH decreased thrombin generation levels of control and DCN-reduced TIME cells, with the exception of NAC. The ETP of the TIME cells after reduction of DCN and incubated with heparins was determined using the CAT system. Representative images from the CAT output are also shown for each heparin used, where the y-axis represents the ETP in nanomolars and the x-axis shows the time in minutes. (A) Treatment without heparin and treatment with all 4 concentrations of UFH (A), LMWH (B), and NAC (C) in a dose-dependent manner. *P < .01, ****P < .00001 (both significant); n = 9; 1-way ANOVA. The y-axis represents the ETP (nanomolars per minute).