Association of T_effgene expression with PFS, mutation load, and IDO1. (A) The association between the T_eff gene signature and PFS in all patients treated with chemoimmunotherapy. (B) The percent of FL patients with high and low T_eff scores (median cut-point) among the 3 mutation load groups. (C) The association between the T_eff gene signature and PFS among mutation load groups. (D) The association between IDO1 (stratified by median IDO1 expression) and PFS among all patients treated with chemoimmunotherapy. (E) The correlation of T_eff expression with levels of IDO1. HRs, 95% CIs, and P values were calculated by using a Cox proportional hazards model, adjusted for age, FLIPI, sex, and response to induction therapy.