Protein network of iron-activated HIV-1 restriction factors in hemolytic anemia. SCD condition or hemin treatment increases expression of HO-1 and FPN. FPN reduces intracellular iron levels stabilizing HIF-1α, and increasing IKBα and p21 production. It also decreases CDK2 expression and inhibits CDK2 activity. Decreased CDK2 activity reduces SAMHD1 phosphorylation and inhibits HIV-1 RT. Decreased CDK2 activity and increased IKBα expression can also inhibit HIV-1 transcription.