Clonal structures of stem/progenitor populations in myeloid BP-CML. (A-C) Data from patients CML002, COL091, and COL091R. Clone identities denoted by circles or bars. (i) Immunophenotypic HSPC populations in patient sample. y-axis: proportion of population as percentage of Lin⁻CD34⁺ cells. (ii) Clonal composition of purified patient populations is based on FISH analysis. x-axis: HSPC population. y-axis: frequency of clones per population. (iii) Clonal hierarchies inferred from FISH data. (D) FISH images: ABL (red); BCR (green); BCR-ABL fusion (F); p53/17p13 (gold); MPO/17q22 (aqua). Atypical BCR-ABL is defined by 1 or 3 BCR-ABL fusions. 17p13 loss is defined by p53 loss. Isochrosome 17q is defined by 3 MPO signals. Numbers of signals detected are indicated.