Nonsynonymous sites of SHM and SHM-induced NLGS are enriched in CDRs. Analyses were performed on all clonal BL tumors for which the complete V region of the most frequent sequence could be determined by capillary sequencing (n = 29). (A) Sites of nonsynonymous SHM plotted per amino acid residue in each IGH gene region. Statistically significant differences in SHM incidence are indicated by asterisks. (B) Sites of nonsynonymous (NS) and synonymous (S) SHM plotted per nucleotide residue in EBV⁺ and EBV^– tumors by CDR or FR. (C) A schematic of an IGH or IGK/IGL gene rearrangement is shown and the location of all NLGS (Asn-X-Ser/Thr amino acid motifs) identified within a complete clonal BL tumor IGH and IGK/IGL sequences are indicated by red circles.