Arp2/3-deficient platelets are cleared from circulation at an increased rate. (A) Clearance of antibody-labeled platelets from circulation in control and Arpc2^fl/flPF4-Cre mice (n = 5). (B) Clearance of antibody-labeled control and Arpc2^fl/flPF4-Cre platelets cotransfused into wild-type recipient mice (n = 6). (C) Platelet count and (D) platelet size in the indicated mice at various time points following antibody-mediated depletion of circulating platelets (n = 7). Blue bars, control; red bars, Arpc2^fl/flPF4-Cre. Data presented as mean ± SEM, *P < .05, **P < .01, ***P < .001.