Regional plot of SNP associations with normal cytogenetic B-ALL. Regional plot showing association with normal cytogenetic B-ALL in a region of chromosome 14 (rs189434316). The x-axis is the position on the chromosome (Mb) and y-axis is the −log₁₀P value of the SNP association with normal cytogenetics B-ALL. Filled colors indicate linkage disequilibrium (LD), as measured by r², with the most significant SNP (shown in purple); red shows a high degree of LD whereas blue indicates lower r². Meta-analyses show that the T allele (MAF = 0.07) increases odds of normal cytogenetic B-ALL by over 3.5-fold compared with controls (P_meta = 5.6 × 10⁻⁹). This association was seen only with normal cytogenetic B-ALL and not observed in other subtypes. CPSF2 is the nearest gene to the association signal.