Manhattan plots for SNP associations with B-ALL by age. (A) Pediatric (<20 years), (B) young adults (20-40 years), and (C) older adults (>40 years). The x-axis indicates the chromosome and the y-axis is the −log₁₀P value from meta-analyses of SNP associations with B-ALL in cohorts 1 and 2. The dashed red line indicates genome-wide significance of P > 5.0 × 10⁻⁸. The SNPs highlighted in red on chromosome 7 (pediatric) are known variants in IKZF1.