Comparison of the hemostatic effect of rFVIIa in FVIII^−/−and Tie2-EPCR/FVIII^−/−mice. FVIII^−/− mice or Tie2-EPCR/FVIII^−/− mice were administered with 0, 1, or 4 mg/kg rFVIIa via the tail vein and subjected to the saphenous vein incision. The average time to achieve hemostasis (A) and blood loss (B) were measured as described in methods (n = 6 to 10 mice/group). * P < .05; ** P < .01; *** P < .001; ns, not statistically significant difference.