Peripheral blood B-lymphocyte depletion and regeneration. (A) B-lymphocyte concentration in blood was determined vs time for individual patients during InO treatment (red circles; n = 72) and during follow-up (triangles; n = 24). Data were fitted to a linear mixed-effects model (green dashed lines = individual model predictions; solid black line = best fit line for overall mean effect of time on B-lymphocyte depletion and regeneration). (B) B-lymphocyte concentration profiles vs time by InO dose (1.2, 1.6, and 1.8 mg/m2 per cycle) for individual patients. (C) InO elimination vs time by percent of BM blasts for individual patients. The 4 panels show serum InO concentration vs time data for InO dosing at cycle 1 day 1 and 15 and cycle 2 days 1 and 15. BM aspirates were collected at screening (circles), cycle 1 day 28 (triangles), and cycle 2 day 28 (squares). Symbol colors are scaled by percent leukemic blasts in BM.
