Figure 4.
In vitro sensitivity of Ba/F3 cells to tyrosine kinase inhibitors. Response of 14 Ba/F3 cell lines expressing Ph-like ALL alterations to targeted agents. Cell viability was measured after 48 hours using CellTitre-Blue viability assay. IC50 values were calculated using serial dilutions and linear regression. The heat map shows IC50 values (log10 scale) according to the color key. Cell lines (columns) and drugs (rows) were ordered by unsupervised clustering.