D-dimer and F1+2 levels for andexanet. D-dimer levels for andexanet alone (phase 1) (A) and in the presence of apixaban (phase 2) (B). F1+2 levels for andexanet alone (phase 1) (C) and in the presence of apixaban (phase 2) (D). Values are means ± standard error of the mean. Dashed lines represent the pre-anticoagulant ranges on day 1 (mean ± 2 SD) for D-dimer and F1+2, respectively.