Immune reconstitution after T-replete CBT and BMT. (A) Bar graph showing T-cells carried with a cord blood and a bone marrow graft. A median of 4 × 10⁶/kg T cells are infused with a cord blood graft compared with 10 times more T cells (45 × 10⁶/kg) infused with a bone marrow graft (P < .0001). The bar graph represents the median, and error bars represent the 25th and 75th centiles. (B) Line graph showing T-cell reconstitution after T-replete CBT and BMT. Despite a 10 times lower number of T cells infused with the cord blood graft, a significantly higher CD3⁺ T-cell recovery is observed 2 months post-CBT compared with after BMT. (C-D) Line graph showing CD4⁺ and CD8⁺ T-cell recovery after CBT and BMT, respectively. The T-cell recovery observed after T-replete CBT was asymmetrically CD4⁺ T-cell biased in contrast to CD8⁺ T-cell biased immune reconstitution after T-replete BMT. The dots represent the median, and the error bars represent the 25th and 75th centile. The green line represents CD4:CD8 ratio plotted on the right Y-axis.