Partial FXIII deficiency does not increase the time to clot formation in murine models of hemostasis. (A-B) F13a^+/+, F13a^+/−, and F13a^−/− mice were subjected to tail transection (A) and saphenous vein puncture (B). (A) Following 3-mm excision of the distal portion of the tail, bleeding was measured as described in “Methods.” Data show time to cessation of bleeding. (B) Following saphenous vein puncture, bleeding was measured after disruption of hemostatic clots as described in “Methods.” The data show average saphenous vein hemostasis times. Each dot represents a separate mouse; lines indicate mean ± SEM.