Event rates of ischemic stroke/SE and major bleeding simulated for various dose regimens of each FXa inhibitor. Left and right boxes for each daily dose represent once-daily and twice-daily administrations, respectively (ie, the box on the right side of X mg represents predictions when X/2 mg is administered twice a day). The horizontal dashed lines represent median predictions for the current dose regimens of each agent marked with downward arrows. The bars represent 95% CIs of the total incidence, derived from 1000 iterations.