ACA-dependent blastic transformation of CML. (A-B) Time course of blastic transformation from emergence of ACAs by ACA type. Patients with ACAs detected at blastic transformation were excluded in panel A but included in panel B. (C-D) Time course of blastic transformation from emergence of ACAs by risk group. Patients with ACAs detected at blastic transformation were excluded in panel C but included in panel D. (E-F) Time course of blastic transformation from initial diagnosis of CML by risk group. Patients with ACAs detected at blastic transformation and those who had BP at initial diagnosis were excluded in panel E but included in panel F.