Impact of 3 intervals on patient survival. (A-B) Time course of ACA emergence (interval 1) by risk group. Patients with ACAs at initial diagnosis were excluded in panel A but included in panel B. (C) Time course of blastic transformation from initial diagnosis (intervals 1 + 2) in patients who developed BP. Patients with BP at initial diagnosis were not included. (D) Patient survival after onset of BP (interval 3) by risk group. (E) Schematic representation of patient survival by risk groups. The OS is determined by time intervals from initial CML diagnosis to ACA emergence (interval 1), from ACA emergence to blastic transformation (interval 2), and survival after onset of blastic transformation (interval 3).