Somatic gene mutations and CNVs in cases of UCD and HHV8⁻/iMCD and FDCS associated with UCD-HVV. Depicted is an unsupervised hierarchical cluster analysis of genetic alterations in UCD, iMCD, and FDCS associated with UCD-HVV. The top portion depicts somatic mutations in all UCD, iMCD, and FDCS cases (green boxes indicate genes mutated in individual cases); the bottom portion depicts CNVs in all UCD, iMCD, and FDCS cases. CNV gains are in red, whereas CNV losses are in blue. Gray boxes indicate genes without abnormalities. White areas/boxes indicate genes not evaluated by targeted sequencing. iMCD-M, HHV8⁻/iMCD with mixed histology; iMCD-PC, HHV8⁻/iMCD with plasma cell histology.