ODSH effect on blood counts in CIT. (A) Nadir platelet counts from mice shown in panel B demonstrating nadir platelet count was significantly higher in ODSH-treated mice vs control (P = .04) (N = 10 per arm). (B) Effect of ODSH SC injection starting 24 hours after administration of 5-FU in hPF4⁺/Cxcl4^−/− mice (red circles, ODSH; blue circles, vehicle control) compared with Cxcl4^−/− mice. Comparison of the curves showed the ODSH curve to be significantly different from the control curve; P < .04. Green circles represent WT animals examined simultaneously. Dashed line represents 100% baseline platelet count. N = 10 animals per arm.