Quantitative relationship between circulating biomarkers and TMTV at diagnosis. TMTV was calculated from initial PET/CT in all 133 patients studied and compared with the number of circulating tumor cells evaluated by ddPCR (CTCs) on peripheral blood cell samples from 68 patients (A), or with the total cfDNA from 61 patients (Eqg/mL) (B). The distributions of the number of CTCs (C) and cfDNA levels (D) according to low or high TMTV are also shown. ****P < .0001; ***P < .001.