Intrinsic clotting profile is altered in AD patient plasma. Intrinsic clotting in ND and AD plasma was assessed by TEG and microtiter plate–based aPTT. (A) TEG trace from normal plasma indicates the origin of the graphed metrics. (B) Representative TEG traces from ND and AD plasma (red = 1 ND donor, blue = 3 AD donors). (C) Tmax. (D) R2. (E) Rate of clot formation (alpha). (F) Representative spectra of ND and AD plasma in the aPTT assay. (G) Clotting start time. (H) Clotting rate (Vmax) in ND and AD plasma assessed in the aPTT assay. All scatter graphs are the mean with SD. *P < .05, **P < .01, ***P < .001. The unpaired Student t test was used to determine statistical significance in panels C-E and G-H.