Intrinsic clotting abnormality is more profound in younger AD patient plasma and correlated inversely with MMSE score. ND and AD plasma samples were separated into a “young” group (50-65 years) and an “old” group (66-80 years), and different TEG parameters were analyzed. Tmax (A), R2 (B), and alpha (C) graphed by age group. (D) Correlation of Tmax and MMSE score. (E) Correlation of R2 and MMSE score. (F) Correlation of alpha V and MMSE score. (G) Correlation of Vmax (from aPTT assay) and MMSE score. In panels D-G, red dots represent ND samples, and blue squares represent AD samples. In panels A-C, 2-way analysis of variance (ANOVA) revealed that age category and group, but not their interaction, were significantly different. In panels D-G, correlations were assessed for all subjects and within the AD group only via Pearson’s method. r = Pearson’s correlation coefficient. *P < .05, **P < .01, ***P < .001.