Trisomy of the DSCR cooperates with Jak3^KI/KIto enhance the CTCL-like disorder. (A) Survival curves comparing Jak3-mutant mice in a euploid vs trisomic (Ts1Rhr) cellular context (4 to 8 mice per group). P values are indicated (log-rank Mantel-Cox test). (B) Histogram plots representing the average weight of spleens in 8- to 10-month-old mice. Data are shown as the mean ± SEM. P values are shown (Student t test). (C) Representative FACS plots of 10-month-old Jak3^KI/WT, Jak3^KI/KI, Ts1Rhr-Jak3^KI/KI, and Ts1Rhr-Jak3^KI/WT mice stained for T-cell markers CD4 and CD8 in PB, BM, SP, Thy, and LN cells. (D) Bar graph comparing the percentage of CD8⁺ cells in PB, BM, SP, Thy, and LN cells of Jak3^KI/KI (black) and Ts1Rhr-Jak3^KI/KI (blue) mice (4 to 8 mice per group; 4 independent experiments). Data are the mean ± SEM. P values are shown (Student t test). (E) Representative FACS plots assessing the expression of CD62L and CCR7 in the CD8⁺Gr1⁺ population of Jak3^KI/KI, Ts1Rhr-Jak3^KI/KI, and Ts1Rhr mice.