Jak3^KI/KICTCL-like disorder is transplantable and is characterized by heterogeneous cell populations. (A) Kinetics of the percentage of the CD4⁺ and CD8⁺ populations in the peripheral blood of sublethally irradiated recipients transplanted with Jak3^KI/KI or Ts1Rhr-Jak3^KI/KI splenic cells. Data are shown as the mean ± SEM (3 to 4 mice per group). P values are shown (Student t test). (B) Representative FACS plots of the CD4 and CD8 splenic cells gated on CD3⁺Gr1⁺ of recipient animals transplanted with Jak3^KI/KI and Ts1Rhr-Jak3^KI/KI cells. (C) Bar graphs showing the proportion of the different T cell populations in recipient animals (Gated on CD3⁺Gr1⁺). Mean ± SEM and P values are indicated (5 mice per group). (D) FACS plot showing the percentage of CD4⁺Gr1⁺ and CD8⁺Gr1⁺ in the peripheral blood at 20 weeks of recipient animals transplanted with sorted CD4⁺ or CD8⁺ donors. (E) Proportion of CD4⁺ and CD8⁺ in the peripheral blood of sublethally irradiated recipients transplanted with CD4⁺ or CD8⁺ sorted cells (n = 5 to 9 mice per group). The presence of the Jak3^KI/KI allele was verified by genotyping CD4⁺Gr1^–, CD4⁺Gr1⁺, CD8⁺Gr1^–, and CD8⁺Gr1⁺ sorted cell populations from peripheral blood.