Progression to ML-DS. CI of ML-DS: (A) TMD07 patients compared with the historical control. (B) Per protocol analysis: Treated TMD07 patients compared with asymptomatic, MRD-negative, untreated TMD07 patients and to the historical control. (C) MRD-positive TMD07 patients compared with MRD-negative TMD07 patients in week 12. Five-year probabilities are given in panels A through C.