Figure 6.
Figure 6. Priming with low-dose LPS restores TRALI in SPF mice. (A) Lung W/D weight ratios, (B) pulmonary PMN numbers, and (C) lung tissue histology analyses in LPS-primed mice (0.1 mg/kg) upon CD4+ T-cell depletion and anti-MHC class I antibody (clones 34-1-2s and AF6-88.5.5.3) infusion into indicated mouse groups. (C) Lung tissue images taken at original magnification ×20 (i,iii,v,vii) and ×40 (ii,iv,vi,viii) (hematoxylin and eosin stain). Representative images of each indicated group are shown. Scale bars represent 100 µM (i,iii,v,vii) and 50 µM (ii,iv,vi,viii). For the statistical analyses, only significant comparisons of interest are shown. Statistical analysis was performed with 1-way ANOVA with a Tukey post hoc test. (A-B) Each dot represents 1 mouse; all error bars represent SD. Figure panels show combinatorial data from 3 experiments.*P < .05, **P < .01, ***P < .001, ****P < .0001.

Priming with low-dose LPS restores TRALI in SPF mice. (A) Lung W/D weight ratios, (B) pulmonary PMN numbers, and (C) lung tissue histology analyses in LPS-primed mice (0.1 mg/kg) upon CD4+ T-cell depletion and anti-MHC class I antibody (clones 34-1-2s and AF6-88.5.5.3) infusion into indicated mouse groups. (C) Lung tissue images taken at original magnification ×20 (i,iii,v,vii) and ×40 (ii,iv,vi,viii) (hematoxylin and eosin stain). Representative images of each indicated group are shown. Scale bars represent 100 µM (i,iii,v,vii) and 50 µM (ii,iv,vi,viii). For the statistical analyses, only significant comparisons of interest are shown. Statistical analysis was performed with 1-way ANOVA with a Tukey post hoc test. (A-B) Each dot represents 1 mouse; all error bars represent SD. Figure panels show combinatorial data from 3 experiments.*P < .05, **P < .01, ***P < .001, ****P < .0001.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal