Design of the 6-month EUMDS classifier. Kaplan-Meier plots of OS (A) and CIP (B) from landmark according to the 6-month EUMDS classifier based on platelet drop >25% and RBC-TD at landmark. (C). Forest plots of HRs of each additional criterion in the 6-month EUMDS classifier according to baseline IPSS-R risk in the landmark cohort. Blue, no criteria; red, either criteria, green, both criteria.