APCP treatment decreases plasma CD73 activity, plasma adenosine level, erythrocyte phosphorylation of AMPK, erythrocyte 2,3-BPG mutase activity, and erythrocyte 2,3-BPG level. (A-B) Plasma CD73 activity and plasma adenosine level in SCD mice with or without APCP treatment. (C-F) Erythrocyte-phosphorylated AMPK level, 2,3-BPG mutase activity, 2,3-BPG concentrations, and P50 in SCD mice with or without APCP treatment. (G-I) Plasma hemoglobin, plasma total bilirubin, and erythrocyte lifespan in SCD mice with or without APCP treatment. Data are expressed as mean ± SEM. n = 5 for each group; *P < .05 vs SCD, Student t test.