ITC data for andexanet alfa or PER977 binding to edoxaban. (A-B) Raw heat data for titrations at 25°C of (A) 100 µM edoxaban into buffer (upper data set) or 13 µM andexanet alfa (lower data set) and (B) 200 µM edoxaban into buffer (upper data set) or 20 µM Per977 (lower data set). All differential heat peaks for 2 µL injections; buffer: phosphate-buffered saline with 1% dimethyl sulfoxide.